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KMID : 0878220100220040056
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Journal of Sasang Constitutional Medicine
2010 Volume.22 No. 4 p.56 ~ p.64
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Anti-inflammatory Activities of Herbal Formulas for Sasang Constitutional Medicine
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Lee Jin-Ah
Ha Hye-Kyung
Lee Ho-Young
Jung Da-Young
Lee Jun-Kyoung
Huang Dae-Sun
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Abstract
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Objectives: 4 herbal formulas (Yanggyeoksanhwa-tang, Yeoldahanso-tang, Cheongsimyeonja-tang and Taeeumjowi-tang) were applied to investigate the anti-inflammatory activities. In many studies, plant-derived anti-inflammatory efficacies have been investigate for their potential inhibitory effects on lipopolysaccharide (LPS)-stimulated macrophages. This study was performed to examine the anti-inflammatory activities of 4 herbal formulas on LPS-stimulated RAW 264.7 cells.
Methods: The productions of nitric oxide (NO), prostaglandin (PG), interleukin(IL)-6 and tumor necrosis factor (TNF)- were examined in the presence of the 4 herbal formulas in RAW 264.7 cells. The cells were incubated with LPS 1 and 4 herbal formulas for 18 hrs. The anti-inflammatory activity of 4 herbal formulas were investigate by carrageenin-induced paw edema in rats. The paw volume was measured at 2 and 4 hrs following carrageenininduced paw edema in rats.
Results: Yanggyeoksanhwa-tang and Cheongsimyeonja-tang showed inhibitory effect on production in LPS-stimulated RAW 264.7 cells and a reduction in carrageenin-induced paw edema on rats. Yanggyeoksanhwa-tang showed inhibitory effect on IL-6 in LPS-stimulated RAW 264.7 cells. 4 herbal formulas not affect on NO and TNF- inhibition in LPS-stimulated RAW 264.7 cells.
Conclusions: These results suggested that Yanggyeoksanhwa-tang and Cheongsimyeonja-tang have anti-inflammatory activity.
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KEYWORD
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Yanggyeoksanhwa-tang (Lianggesanhuo-tang), Yeoldahanso-tang (Reduohanshao-tang), Cheongsimyeonja-tang (Qingxinlianzi-tang), Taeeumjowi-tang (Taiyintiaowei-tang), Anti-inflammation
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